5 Facts you should know about

IgA nephropathy

Primary IgA nephropathy is characterized by the deposition of the IgA antibody in the glomerulus

Proteinuria is a key prognostic indicator of progression in IgA nephropathy

The progression of IgA nephropathy is driven by two critical pathways—Endothelin-1 (ET-1) and Angiotensin II (Ang II)

Lower proteinuria levels are critical to preserving kidney function

In non-aggressive IgA nephropathy, there is traditionally a slow progression to chronic kidney failure in 20%–40% of cases

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