Rare Nephrology News
Disease Profile
Cronkhite-Canada disease
Prevalence estimates on Rare Medical Network websites are calculated based on data available from numerous sources, including US and European government statistics, the NIH, Orphanet, and published epidemiologic studies. Rare disease population data is recognized to be highly variable, and based on a wide variety of source data and methodologies, so the prevalence data on this site should be assumed to be estimated and cannot be considered to be absolutely correct.
Unknown
Age of onset
Elderly
ICD-10
D12.6
Inheritance
Autosomal dominant A pathogenic variant in only one gene copy in each cell is sufficient to cause an autosomal dominant disease.
Autosomal recessive Pathogenic variants in both copies of each gene of the chromosome are needed to cause an autosomal recessive disease and observe the mutant phenotype.
X-linked
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
X-linked
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
Mitochondrial or multigenic Mitochondrial genetic disorders can be caused by changes (mutations) in either the mitochondrial DNA or nuclear DNA that lead to dysfunction of the mitochondria and inadequate production of energy.
Multigenic or multifactor Inheritance involving many factors, of which at least one is genetic but none is of overwhelming importance, as in the causation of a disease by multiple genetic and environmental factors.
Not applicable
Other names (AKA)
Polyposis skin pigmentation alopecia fingernail changes
Categories
Congenital and Genetic Diseases; Digestive Diseases; Rare Cancers;
Summary
Cronkhite-Canada
Symptoms
This table lists symptoms that people with this disease may have. For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed. This information comes from a database called the Human Phenotype Ontology (HPO) . The HPO collects information on symptoms that have been described in medical resources. The HPO is updated regularly. Use the HPO ID to access more in-depth information about a symptom.
| Medical Terms | Other Names |
Learn More:
HPO ID
|
|---|---|---|
| 80%-99% of people have these symptoms | ||
| Diarrhea |
Watery stool
|
0002014 |
| Dystrophic fingernails |
Poor fingernail formation
|
0008391 |
| Dystrophic toenail |
Poor toenail formation
|
0001810 |
| Generalized hyperpigmentation | 0007440 | |
| Hamartomatous polyposis | 0004390 | |
| Hypoplastic toenails |
Underdeveloped toenails
|
0001800 |
| Intestinal polyposis | 0200008 | |
| Malabsorption |
Intestinal malabsorption
|
0002024 |
| Patchy alopecia |
Patchy baldness
|
0002232 |
| 30%-79% of people have these symptoms | ||
| Abdominal pain |
Pain in stomach
Stomach pain
[ more ] |
0002027 |
|
Low number of red blood cells or hemoglobin
|
0001903 | |
| Anorexia | 0002039 | |
| Aplasia/Hypoplasia of the eyebrow |
Absence of eyebrow
Lack of eyebrow
Missing eyebrow
[ more ] |
0100840 |
| Cachexia |
Wasting syndrome
|
0004326 |
| Fatigue |
Tired
Tiredness
[ more ] |
0012378 |
| Lymphedema |
Swelling caused by excess lymph fluid under skin
|
0001004 |
| Sparse body hair | 0002231 | |
| 5%-29% of people have these symptoms | ||
|
Clouding of the lens of the eye
Cloudy lens
[ more ] |
0000518 | |
| Colon |
0003003 | |
| Furrowed tongue |
Grooved tongue
|
0000221 |
| Gastrointestinal carcinoma | 0002672 | |
| Hepatomegaly |
Enlarged liver
|
0002240 |
| Hypogeusia |
Decreased taste
Decreased taste sensation
[ more ] |
0000224 |
| Macrocephaly |
Increased size of skull
Large head
Large head circumference
[ more ] |
0000256 |
| 0001250 | ||
| Splenomegaly |
Increased spleen size
|
0001744 |
| Stomach cancer | 0012126 | |
| Tapered finger |
Tapered fingertips
Tapering fingers
[ more ] |
0001182 |
| Percent of people who have these symptoms is not available through HPO | ||
| Alopecia |
Hair loss
|
0001596 |
| Clubbing |
Clubbing of fingers and toes
|
0001217 |
| Clubbing of fingers |
Clubbed fingers
Clubbing (hands)
Finger clubbing
[ more ] |
0100759 |
| Glossitis |
Inflammation of the tongue
Smooth swollen tongue
[ more ] |
0000206 |
| Hematochezia |
Rectal bleeding
|
0002573 |
| Hyperpigmentation of the skin |
Patchy darkened skin
|
0000953 |
| Hypocalcemia |
Low blood calcium levels
|
0002901 |
| Hypokalemia |
Low blood potassium levels
|
0002900 |
| Hypomagnesemia |
Low blood magnesium levels
|
0002917 |
| Muscle weakness |
Muscular weakness
|
0001324 |
| Nail dysplasia |
Atypical nail growth
|
0002164 |
| Nail dystrophy |
Poor nail formation
|
0008404 |
| Paresthesia |
Pins and needles feeling
Tingling
[ more ] |
0003401 |
| 0002243 | ||
| Sporadic |
No previous family history
|
0003745 |
| Thromboembolism | 0001907 | |
| Vomiting |
Throwing up
|
0002013 |
| Xerostomia |
Dry mouth
Dry mouth syndrome
Reduced salivation
[ more ] |
0000217 |
Related diseases
Related diseases are conditions that have similar signs and symptoms. A health care provider may consider these conditions in the table below when making a diagnosis. Please note that the table may not include all the possible conditions related to this disease.
|
Conditions with similar signs and symptoms from Orphanet
|
|---|
|
Differential diagnosis includes familial adenomatous polyposis, hyperplastic polyposis syndrome, cap polyposis, juvenile polyposis syndrome, Peutz-Jeghers syndrome and Cowden syndrome (see these terms), as well as lipomatous polyposis, inflammatory polyposis and lymphomatous polyposis.
Visit the Orphanet disease page for more information.
|
Organizations
Support and advocacy groups can help you connect with other patients and families, and they can provide valuable services. Many develop patient-centered information and are the driving force behind research for better treatments and possible cures. They can direct you to research, resources, and services. Many organizations also have experts who serve as medical advisors or provide lists of doctors/clinics. Visit the group’s website or contact them to learn about the services they offer. Inclusion on this list is not an endorsement by GARD.
Organizations Supporting this Disease
-
American Hair Loss Association
23679 Calabasas Road # 682
Calabasas, CA 91301-1502
E-mail: [email protected]
Website: https://americanhairloss.org
Organizations Providing General Support
-
American Gastroenterological Association
4930 Del Ray Avenue
Bethesda, MD 20814
Telephone: 301–654–2055
Fax: 301–654–5920
E-mail: [email protected]
Website: https://www.gastro.org/patient
Learn more
These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.
Where to Start
- The National Organization for Rare Disorders (NORD) has a report for patients and families about this condition. NORD is a patient advocacy organization for individuals with rare diseases and the organizations that serve them.
In-Depth Information
- Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
- The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
- Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine.
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Cronkhite-Canada disease. Click on the link to view a sample search on this topic.
Selected Full-Text Journal Articles
- Kopácová M, Urban O, Cyrany J et al. Cronkhite-Canada Syndrome: Review of the Literature. Gastroenterol Res Pract. 2013;2013:856873.
References
- Kao KT, Patel JK, Pampati V. Gastroenterol Res Pract. Epub 2009 Aug 25; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2732131/?tool=pubmed. Accessed 5/31/2015.
- Serwin AB. Cronkhite-Canada syndrome. eMedicine. October 23, 2014; https://emedicine.medscape.com/article/1096789-overview. Accessed 5/31/2015.
- Cronkhite-Canada Syndrome. National Organization for Rare Disorders (NORD). 2005; https://rarediseases.org/rare-diseases/cronkhite-canada-syndrome/. Accessed 5/31/2015.