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Disease Profile

Florid cemento-osseous dysplasia

Prevalence estimates on Rare Medical Network websites are calculated based on data available from numerous sources, including US and European government statistics, the NIH, Orphanet, and published epidemiologic studies. Rare disease population data is recognized to be highly variable, and based on a wide variety of source data and methodologies, so the prevalence data on this site should be assumed to be estimated and cannot be considered to be absolutely correct.


US Estimated

Europe Estimated

Age of onset




D16.4 D16.5


Autosomal dominant A pathogenic variant in only one gene copy in each cell is sufficient to cause an autosomal dominant disease.


Autosomal recessive Pathogenic variants in both copies of each gene of the chromosome are needed to cause an autosomal recessive disease and observe the mutant phenotype.


dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.


recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.


Mitochondrial or multigenic Mitochondrial genetic disorders can be caused by changes (mutations) in either the mitochondrial DNA or nuclear DNA that lead to dysfunction of the mitochondria and inadequate production of energy.


Multigenic or multifactor Inheritance involving many factors, of which at least one is genetic but none is of overwhelming importance, as in the causation of a disease by multiple genetic and environmental factors.


Not applicable


Other names (AKA)

florid osseous dysplasia; focal cemento-osseous dysplasia


Mouth Diseases


Florid cemento-osseous dysplasia (FCOD) is a condition that occurs in the jaw bone, especially close to where the teeth are formed.[1][2] People with FCOD develop lesions in the jaw, were spots of normal bone are replaced with a mix of connective tissue and abnormal bone.[1][3] The lesions are often found in equal numbers and size on both sides of the jaw. People with FCOD rarely have symptoms and it is usually found with dental x-rays during a routine dental examination.

The cause of FCOD is unknown, and it does not usually run in families. It mainly occurs in middle aged women of African American and Asian descent.[1][2] The number, size, and shape of the lesions can be different from person to person. Occasionally the lesions expand or get infected and may cause discomfort, pain, or mild disfigurement.[1][2] Treatment for this condition is observation and avoiding infections of the mouth and teeth. The long-term outlook for people with FCOD is good.


Usually florid cemento-osseous dysplasia causes no symptoms. It is often found by accident while getting dental x-rays for some other purpose.[2] Occasionally however, the lesions get infected and may expand causing discomfort, pain, and/or mild disfigurement.[2]


The cause of florid cemento-osseous dysplasia (FCOD) is not known.[1][2]


Diagnosis of florid cemento-osseous dysplasia (FCOD) relies on the x-ray findings of the lesions as well as the clinical signs and symptoms. FCOD can look like other, more serious conditions, and it's important to make sure that FCOD is the correct diagnosis.[2] Other conditions that can look like FCOD include: 


In most people, florid cemento-osseous dysplasia (FCOD) does not require treatment. People with this condition should be followed with dental x-rays every 2-3 years.[2][3][4] In addition, because infections are difficult to treat in people with FCOD, sometimes people with FCOD take antibiotics to help prevent infections. If someone with FCOD does get an infection of the jaw, treatment may include surgery to clean out the infection.[2]

Learn more

These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.

In-Depth Information

  • Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Florid cemento-osseous dysplasia. Click on the link to view a sample search on this topic.


    1. Das BK, Das SN, Gupta A, Nayak S. Florid cemento-osseous dysplasia. Jl Oral Maxillofac Pathol. Jan-Apr, 2013; 17(1):150-159. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3687180.
    2. Fenerty S, Shaw W, Verma R, Syed AB, Kuklani R, Yang J, Ali S. Florid cemento-osseous dysplasia: review of an uncommon fibro-osseous lesion of the jaw with important clinical implications. Skeletal Radiol. 2017; 46(5):581-590. https://www.ncbi.nlm.nih.gov/pubmed/28194495.
    3. Aiuto R, Gucciardino F, Rapetti R, Siervo S, Bianchi A-E. Management of symptomatic florid cemento-osseous dysplasia: Literature review and a case report. J Clin Exp Dent. 2018; 10(3):e29105. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923893.
    4. Consolaro A, Paschoal SRB, Ponce JB, Miranda DAO. Florid cemento-osseous dysplasia: a contraindication to orthodontic treatment in compromised areas. Dental Press J Orthod. May-June, 2018; 23(3):26-34. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072450/pdf.

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