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Disease Profile
Panuveitis
Prevalence estimates on Rare Medical Network websites are calculated based on data available from numerous sources, including US and European government statistics, the NIH, Orphanet, and published epidemiologic studies. Rare disease population data is recognized to be highly variable, and based on a wide variety of source data and methodologies, so the prevalence data on this site should be assumed to be estimated and cannot be considered to be absolutely correct.
Unknown
Age of onset
All ages
ICD-10
H44.1
Inheritance
Autosomal dominant A pathogenic variant in only one gene copy in each cell is sufficient to cause an autosomal dominant disease.
Autosomal recessive Pathogenic variants in both copies of each gene of the chromosome are needed to cause an autosomal recessive disease and observe the mutant phenotype.
X-linked
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
X-linked
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
Mitochondrial or multigenic Mitochondrial genetic disorders can be caused by changes (mutations) in either the mitochondrial DNA or nuclear DNA that lead to dysfunction of the mitochondria and inadequate production of energy.
Multigenic or multifactor Inheritance involving many factors, of which at least one is genetic but none is of overwhelming importance, as in the causation of a disease by multiple genetic and environmental factors.
Not applicable
Other names (AKA)
Inflammation of the whole uveal tract; Total uveitis; Diffuse uveitis
Categories
Eye diseases
Summary
Panuveitis is inflammation of all layers of the uvea of the eye, which includes the iris, ciliary body, and choroid. These make up the middle layer of the eye.[1] The condition can also affect the lens, retina, optic nerve, and vitreous, causing reduced vision or blindness.[2] Signs and symptoms may include eye redness and pain; blurring; light sensitivity; decreased vision; and seeing floaters.[1] It can last for a short time or can occur chronically. Severe cases may recur many times.[2] In many cases the specific cause is unknown, but in some cases it occurs in association with other eye conditions, or with another condition or infection that also affects other body parts.[1][2] Early treatment is needed and may include eye drops to reduce inflammation and pain; and/or oral medications or injections in severe cases.[1]
Symptoms
Cause
Treatment
Immunomodulating drugs (drugs that alter the body's immune response) are needed if the inflammation cannot be controlled with corticosteroids or if active inflammation interferes with activities of daily living.[3][5] Cycloplegics (eye drops that temporarily paralyze the ciliary body) are used to help with pain due to ciliary spasms.[3]
Forms of uveitis due to infectious agents are treated by specific antimicrobial therapy (
FDA-Approved Treatments
The medication(s) listed below have been approved by the Food and Drug Administration (FDA) as orphan products for treatment of this condition. Learn more orphan products.
- Adalimumab(Brand name: Humira) Manufactured by AbbVie Inc.
FDA-approved indication: September 2018, adalimumab (Humira) received expanded approval for the treatment of non-infectious intermediate, posterior, and panuveitis to include pediatric patients 2 years of age and older. It was approved for use in adults with non-infectious intermediate, posterior, and panuveitis in June 2016.
National Library of Medicine Drug Information Portal
Medline Plus Health Information - Dexamethasone Intravitreal Implant(Brand name: Ozurdex) Manufactured by Allergan
FDA-approved indication: For treating non-infectious ocular inflammation, or uveitis, affecting eye's posterior segment
National Library of Medicine Drug Information Portal
Organizations
Support and advocacy groups can help you connect with other patients and families, and they can provide valuable services. Many develop patient-centered information and are the driving force behind research for better treatments and possible cures. They can direct you to research, resources, and services. Many organizations also have experts who serve as medical advisors or provide lists of doctors/clinics. Visit the group’s website or contact them to learn about the services they offer. Inclusion on this list is not an endorsement by GARD.
Organizations Supporting this Disease
-
American Uveitis Society
Office of the Executive Secretary
700 18th Street South Suite 601
Birmingham, AL 35233
Telephone: +1-205-325-8507
Website: https://uveitissociety.org/
Social Networking Websites
- Visit the following Facebook groups related to Panuveitis:
Uveitis (Community)
Uveitis (Community)
Ocular Immunology and Uveitis Foundation
Uveitis Awareness Worldwide
Kids with Uveitis
Learn more
These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.
Where to Start
- The American Academy of Ophthalmology Web site has an information page on Panuveitis. Their Web site is dedicated to educating people about eye diseases and conditions and the preservation of eye health.
- MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
- The Merck Manual provides information on this condition for patients and caregivers.
- The National Eye Institute (NEI) was established by Congress in 1968 to protect and prolong the vision of the American people. Click on the link to view information on this topic.
In-Depth Information
- Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
- The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Panuveitis. Click on the link to view a sample search on this topic.
References
- Kierstan Boyd. What is uveitis?. American Academy of Ophthalmology. March 1, 2014; https://www.geteyesmart.org/eyesmart/diseases/uveitis/index.cfm.
- Facts About Uveitis. National Eye Institute. August, 2011; https://nei.nih.gov/health/uveitis/uveitis.
- Reema Bansal, Vishali Gupta, and Amod Gupta. Current approach in the diagnosis and management of panuveitis. Indian Journal of Ophthalmology. Jan-Feb, 2010; 58(1):45-54. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2841373/.
- Deuter CM1, Stübiger N, Siepmann K, Derse M, Zierhut M. [Familial uveitis. Forms and incidence in patients at the University Eye Hospital Tubingen]. Ophthalmologe. September, 2003; 100(9):713-719.
- James T Rosenbaum. Uveitis: Treatment. UpToDate. Waltham, MA: UpToDate; October, 2016;
- Emmett T. Cunningham, Jr. Uveitis. Merck Manual. October, 2014; https://www.merckmanuals.com/professional/eye-disorders/uveitis-and-related-disorders/overview-of-uveitis.
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